Photo of Professor Anton Emmanuel

Professor Anton Emmanuel

Telephone:

Email:

Location:

  • University College Hospital
  • National Hospital for Neurology and Neurosurgery

GMC/GDC number:

3460674

Professional background

Anton Emmanuel obtained his medical degree from London University. He is a professor in neuro-gastroenterology at University College London and consultant gastroenterologist at UCLH and the National Hospital for Neurology and Neurosurgery (Queen Square). Prior to this he was senior lecturer at Imperial College and honorary consultant gastroenterologist at St Mark's Hospital.

His clinical work encompasses being director of the GI Physiology Unit at University College Hospital, as well as providing a neurogastroenterology service. The Physiology Unit provides state-of-the-art testing of oesophageal and anorectal function, as well as a wide range of therapies for patients with neurogastro and functional disorders – biofeedback, neuromodulation, transanal irrigation, hypnotherapy, psychological services, dietetic input. 

His research includes gut neurophysiology and the study of the aetiology and management of functional gastrointestinal disorders of the upper and lower gut. He is editor in chief of Clinical Medicine and medical director of publishing at the Royal College of Physicians.

Specialties

Research interests

  • Gut dysfunction in neurological disease (SCI, MS, Parkinson’s, muscles disease)
  • Chronic intestinal pseudo-obstruction
  • Low anterior resection syndrome
  • Gut dysfunction in systemic sclerosis and endometriosis
  • IBS and chronic constipation
  • Faecal incontinence and pelvic floor dysfunction
  • Gastro-oesophageal reflux

Publications

Most recent publications:

  • The management of adult patients with severe chronic small intestinal dysmotility. Nightingale JMD, Paine P, McLaughlin J, Emmanuel A, Martin JE, Lal S; Small Bowel and Nutrition Committee and the Neurogastroenterology and Motility Committee of the British Society of Gastroenterology. Gut. 2020 Aug 21:gutjnl-2020-321631. doi: 10.1136/gutjnl-2020-321631
  • Impact of symptom severity in patients with diarrhoea-predominant irritable bowel syndrome (IBS-D): results from two separate surveys of HCPs and patients with IBS-D. Emmanuel A, Goosey RW, Wiseman G, Baker S, Törnblom H. BMC Gastroenterol. 2020;20(1):127. doi: 10.1186/s12876-020-01252-9.
  • Creation and validation of a new tool for the monitoring efficacy of neurogenic bowel dysfunction treatment on response: the MENTOR tool. Emmanuel A, Krogh K, Kirshblum S, Christensen P, Spinelli M, van Kuppevelt D, Abel R, Leder D, Santacruz BG, Bain K, Passananti V. Spinal Cord. 2020 Jan 27. doi: 10.1038/s41393-020-0424-8.
  • Neurogenic bowel dysfunction. Emmanuel A. F1000Res. Faculty Rev 2019 Oct;8:1800. doi: 10.12688/f1000research.20529.1
  • Colonic transit, high-resolution anorectal manometry and MRI defecography study of constipation in Parkinson's disease. De Pablo-Fernández E, Passananti V, Zárate-López N, Emmanuel A, Warner T. Parkinsonism Relat Disord. 2019 Aug 28. pii: S1353-8020(19)30372-4.
  • The international anorectal physiology working group (IAPWG) recommendations: Standardized testing protocol and the London classification for disorders of anorectal function. Carrington EV, Heinrich H, Knowles CH, Fox M, Rao S, Altomare DF, Bharucha AE, Burgell R, Chey WD, Chiarioni G, Dinning P, Emmanuel A, Farouk R, Felt-Bersma RJF, Jung KW, Lembo A, Malcolm A, Mittal RK, Mion F, Myung SJ, O'Connell PR, Pehl C, María Remes Troche J, Reveille RM, Vaizey CJ, Vitton V, Whitehead WE, Wong RK, Scott SM; All members of the International Anorectal Physiology Working Group. Neurogastroenterol Motil. 2019 Aug 12:e13679.
  • Oropharyngeal dysphagia management in cervical spinal cord injury patients: an exploratory survey of variations to care across specialised and non-specialised units. McRae J, Smith C, Beeke S, Emmanuel A. Spinal Cord Ser Cases. 2019;5:31
  • High-resolution anal manometry: Repeatability, validation, and comparison with conventional manometry. Gosling J, Plumb A, Taylor SA, Cohen R, Emmanuel AV. Neurogastroenterol Motil. 2019;31:e13591.
  • Anti-muscarinic drugs increase rectal compliance and exacerbate constipation in chronic spinal cord injury : Anti-muscarinic drug effect on neurogenic bowel. Paily A, Preziosi G, Trivedi P, Emmanuel A. Spinal Cord. 2019 Feb 25. doi: 10.1038/s41393-019-0263-7.
  • Adherence with a low-FODMAP diet in irritable bowel syndrome: are eating disorders the missing link? Mari A, Hosadurg D, Martin L, Zarate-Lopez N, Passananti V, Emmanuel A. Eur J Gastroenterol Hepatol. 2019 Feb;31(2):178-182.
  • Neurogenic bowel dysfunction in patients with multiple sclerosis: prevalence, impact, and management strategies.Preziosi G, Gordon-Dixon A, Emmanuel A. Degener Neurol Neuromuscul Dis. 2018 Dec 6;8:79-90
  • Understanding symptom burden and attitudes to irritable bowel syndrome with diarrhoea: Results from patient and healthcare professional surveys. Törnblom H, Goosey R, Wiseman G, Baker S, Emmanuel A. United European Gastroenterol J. 2018 Nov;6(9):1417-1427
  • UK clinical experience up to 52?weeks with linaclotide for irritable bowel syndrome with constipation. Yiannakou Y, Agrawal A, Allen PB, Arebi N, Brown SR, Eugenicos MP, Farmer AD, McLain-Smith S, McLaughlin J, Sanders DS, Lawrance D, Emmanuel A. Therap Adv Gastroenterol. 2018 Oct 3;11:1756284818798791.
  • Pathophysiology and Treatment of Gastrointestinal Motility Disorders in the Acutely Ill. Deane AM, Chapman MJ, Reintam Blaser A, McClave SA, Emmanuel A. Nutr Clin Pract. 2019 Feb;34(1):23-36.
  • The patient burden of opioid-induced constipation: New insights from a large, multinational survey in five European countries. Andresen V, Banerji V, Hall G, Lass A, Emmanuel AV. United European Gastroenterol J. 2018 Oct;6(8):1254-1266.
  • Posterior Tibial Nerve Stimulation for the Treatment of Fecal Incontinence Following Obstetric Anal Sphincter Injury. Sanagapalli S, Harrington S, Zarate-Lopez N, Emmanuel A. Neuromodulation. 2018 Aug 28. doi: 10.1111/ner.12844.
  • Multiple symptoms, multiple systems. Emmanuel AV. Frontline Gastroenterol. 2018 Jul;9(3):169.
  • Translating promising strategies for bowel and bladder management in spinal cord injury. Wheeler TL; Bowel and Bladder Workshop Participants, de Groat W, Eisner K, Emmanuel A, French J, Grill W, Kennelly MJ, Krassioukov A, Gallo Santacruz B, Biering-Sørensen F, Kleitman J. Exp Neurol. 2018 Aug;306:169-176
  • When all seems lost: management of refractory constipation-Surgery, rectal irrigation, percutaneous endoscopic colostomy, and more. Wilkinson-Smith V, Bharucha AE, Emmanuel A, Knowles C, Yiannakou Y, Corsetti M. Neurogastroenterol Motil. 2018 May;30(5):e13352
  • Efficacy of Percutaneous Posterior Tibial Nerve Stimulation for the Management of Fecal Incontinence in Multiple Sclerosis: A Pilot Study. Sanagapalli S, Neilan L, Lo JYT, Anandan L, Liwanag J, Raeburn A, Athanasakos E, Zarate-Lopez N, Emmanuel A. Neuromodulation. 2018;21:682-687
  • Impaired motility in Barrett's esophagus: A study using high-resolution manometry with physiologic challenge. Sanagapalli S, Emmanuel A, Leong R, Kerr S, Lovat L, Haidry R, Banks M, Graham D, Raeburn A, Zarate-Lopez N, Sweis R. Neurogastroenterol Motil. 2018 Mar 15.
  • Irritable bowel syndrome diagnosis and management: A simplified algorithm for clinical practice. Moayyedi P, Mearin F, Azpiroz F, Andresen V, Barbara G, Corsetti M, Emmanuel A, Hungin APS, Layer P, Stanghellini V, Whorwell P, Zerbib F, Tack J.United European Gastroenterol J. 2017;5:773-788.
  • Urinary, bowel and sexual symptoms in a cohort of patients with Friedreich's ataxia. Lad M, Parkinson MH, Rai M, Pandolfo M, Bogdanova-Mihaylova P, Walsh RA, Murphy S, Emmanuel A, Panicker J, Giunti P. Orphanet J Rare Dis. 2017;12:158.
  • Review article: dyssynergic defaecation and biofeedback therapy in the pathophysiology and management of functional constipation. Skardoon GR, Khera AJ, Emmanuel AV, Burgell RE. Aliment Pharmacol Ther. 2017;46:410-423.
  • A physiological study of the anorectal reflex in patients with functional anorectal and defecation disorders. Thiruppathy K, Mason J, Akbari K, Raeburn A, Emmanuel A. J Dig Dis. 2017 Mar 6. doi: 10.1111/1751-2980.12462
  • International spinal cord injury bowel function basic data set (Version 2.0). Krogh K, Emmanuel A, Perrouin-Verbe B, Korsten MA, Mulcahey MJ, Biering-Sørensen F. Spinal Cord. 2017 Feb 14. doi: 10.1038/sc.2016.189
  • Opioid-Induced Constipation and Bowel Dysfunction: A Clinical Guideline. Müller-Lissner S, Bassotti G, Coffin B, Drewes AM, Breivik H, Eisenberg E, Emmanuel A, Laroche F, Meissner W, Morlion B. Pain Med. 2016 Dec 29. pii: pnw255. doi: 10.1093/pm/pnw255
  • An expert consensus definition of failure of a treatment to provide adequate relief (F-PAR) for chronic constipation - an international Delphi survey. Tack J, Boardman H, Layer P, Schiefke I, Jayne D, Scarpignato C, Fox M, Frieling T, Ducrotte P, Hamdy S, Gill K, Ciriza de Los Rios C, Felt-Bersma R, De Looze D, Stanghellini V, Drewes AM, Simrén M, Pehl C, Hoheisel T, Leodolter A, Rey E, Dalrymple J, Emmanuel A. Aliment Pharmacol Ther. 2017 Feb;45(3):434-442
  • Faecal biomarker patterns in patients with symptoms of irritable bowel syndrome. Emmanuel A, Landis D, Peucker M, Hungin AP. Frontline Gastroenterol. 2016 Oct;7(4):275-282
  • Quality of life in the following fistulotomy - short term follow up. Owen HA, Buchanan GN, Schizas A, Emmanuel A, Cohen R, Williams AB.Colorectal Dis. 2016 (in print)
  • Long-Term Cost-Effectiveness of Transanal Irrigation in Patients with Neurogenic Bowel Dysfunction. Emmanuel A, Kumar G, Christensen P, Mealing S, Størling ZM, Andersen F, Kirshblum S. PLoS One. 2016 Aug 24;11(8):e0159394
  • Current management of the gastrointestinal complications of systemic sclerosis. Emmanuel A. Nature Rev Gastroenterol Hepatol. 2016;13:461-72.
  • Age, Gender and Women's Health and the Patient. Houghton LA, Heitkemper M, Crowell M, Emmanuel A, Halpert A, McRoberts JA, Toner B. Gastroenterology. 2016 Feb 15. pii: S0016-5085(16)00183-9. doi: 10.1053/j.gastro.2016.02.017. [Epub ahead of print]
  • Effectiveness of percutaneous tibial nerve stimulation in managing refractory constipation. Kumar L, Liwanag J, Athanasakos E, Raeburn A, Zarate-Lopez N, Emmanuel AV. Colorectal Dis. 2016 May 20. doi: 10.1111/codi.13388. [Epub ahead of print]
  • Neurogenic lower urinary tract dysfunction: Clinical management recommendations of the Neurologic Incontinence committee of the fifth International Consultation on Incontinence 2013. Drake MJ, Apostolidis A, Cocci A, Emmanuel A, Gajewski JB, Harrison SC, Heesakkers JP, Lemack GE, Madersbacher H, Panicker JN, Radziszewski P, Sakakibara R, Wyndaele JJ. Neurourol Urodyn. 2016;35:657-65
  • Long-term efficacy and safety of transanal irrigation in multiple sclerosis. Passananti V, Wilton A, Preziosi G, Storrie JB, Emmanuel A. Neurogastroenterol Motil. 2016 Apr 26. doi: 10.1111/nmo.12833. [Epub ahead of print]
  • Libertas: a phase II placebo-controlled study of NRL001 in patients with faecal incontinence showed an unexpected and sustained placebo response. Siproudhis L, Graf W, Emmanuel A, Walker D, Shing RN, Pediconi C, Pilot J, Wexner S, Scholefield J. Int J Colorectal Dis. 2016;31:1205-16.
  • Synchronized functional anal sphincter assessment: maximizing the potential of anal vector manometry and 3-D anal endosonography. Schizas AM, Ahmad AN, Emmanuel AV, Williams AB. Neurogastroenterol Motil. 2016:28:1075-82
  • Altered Colorectal Compliance and Anorectal Physiology in Upper and Lower Motor Neurone Spinal Injury May Explain Bowel Symptom Pattern. Trivedi PM, Kumar L, Emmanuel AV. Am J Gastroenterol. 2016 Feb. Apr;111:552-60.
  • Comparative quantitative assessment of global small bowel motility using magnetic resonance imaging in chronic intestinal pseudo-obstruction and healthy controls. Menys A, Butt S, Emmanuel A, Plumb AA, Fikree A, Knowles C, Atkinson D, Zarate N, Halligan S, Taylor SA. Neurogastroenterol Motil. 2016;28:376-83
  • Bladder and bowel dysfunction affect quality of life. A cross sectional study of 60 patients with aquaporin-4 antibody positive Neuromyelitis Optica spectrum disorder. Mutch K, Zhao S, Hamid S, Methley A, Elsone L, Singh G, Young C, Emmanuel A, Panicker J, Jacob A. Mult Scler Relat Disord. 2015;4:614-8
  • Global audit on bowel perforations related to transanal irrigation. Christensen P, Krogh K, Perrouin-Verbe B, Leder D, Bazzocchi G, Petersen Jakobsen B, Emmanuel AV.Tech Coloproctol. 2016;20:109-15.
  • Aberrant Motility in Unaffected Small Bowel is Linked to Inflammatory Burden and Patient Symptoms in Crohn's Disease. Menys A, Makanyanga J, Plumb A, Bhatnagar G, Atkinson D, Emmanuel A, Taylor SA. Inflamm Bowel Dis. 2016;22:424-32.
  • Double blinded randomised multicentre study to investigate the effect of stimulation parameter changes on sacral nerve stimulation for constipation.Thomas GP, Duelund-Jakobsen J, Dudding TC, Bradshaw E, Nicholls RJ, Alam A, Emmanuel A, Thin N, Knowles CH, Laurberg S, Vaizey CJ. Colorectal Dis. 2015. ;17:990-5
  • Lack of effect of sacral nerve stimulation for incontinence in patients with systemic sclerosis. Butt S, Alam A, Cohen R, Krogh K, Buntzen S, Emmanuel A. Colorectal Dis. 2015.17:903-7
  • Randomized clinical trial of sacral versus percutaneous tibial nerve stimulation in patients with faecal incontinence. Thin NN, Taylor SJ, Bremner SA, Emmanuel AV, Hounsome N, Williams NS, Knowles CH; on behalf of the Neuromodulation Trial Study Group Br J Surg. 201;102(4):349-58
  • Neurostimulation of the Gastrointestinal Tract: Review of Recent Developments. Abell TL, Chen J, Emmanuel A, Jolley C, Sarela AI, Törnblom H. Neuromodulation. 2015;18(3):221-7
  • Prospective regenerative medicine therapies for obstetric trauma-induced fecal incontinence. Parmar N, Kumar L, Emmanuel A, Day RM. Regen Med. 2014;9(6):831-40.
  • Consensus best practice pathway of the UK scleroderma study group: gastrointestinal manifestations of systemic sclerosis. Hansi N, Thoua N, Carulli M, Chakravarty K, Lal S, Smyth A, Herrick A, Ogunbiyi O, Shaffer J, Mclaughlin J, Denton C, Ong V, Emmanuel AV, Murray CD. Clin Exp Rheumatol. 2014 Nov-Dec;32(6 Suppl 86):S-214-21
  • Coping with common gastrointestinal symptoms in the community: a global perspective on heartburn, constipation, bloating, and abdominal pain/discomfort Hunt R, Quigley E, Abbas Z, Eliakim A, Emmanuel A, Goh KL, Guarner F, Katelaris P, Smout A, Umar M, Whorwell P, Johanson J, Saenz R, Besançon L, Ndjeuda E, Horn J, Hungin P, Jones R, Krabshuis J, LeMair A; Review Team. J Clin Gastroenterol. 2014 Aug;48(7):567-78
  • Factors affecting satisfaction with treatment in European women with chronic constipation: An internet survey. Emmanuel A, Quigley EM, Simrén M, Feng Y, Müller-Lissner S, Urbain D, Tack J, Bredenoord AJ, Sabaté JM, Yiannakou Y, Andresen V, Cuomo R, Rey E, Gryp RS, Vandeplassche L, Solomon D. United European Gastroenterol J. 2013 Oct;1(5):375-84
  • Prucalopride improves bowel function and colonic transit time in patients with chronic constipation: an integrated analysis. Emmanuel A, Cools M, Vandeplassche L, Kerstens R. Am J Gastroenterol. 2014 Jun;109(6):887-94