Dr Thomas Barber
Telephone:
Location:
- National Hospital for Neurology and Neurosurgery
GMC/GDC number:
7041149
Professional background
Dr Thomas Barber is an honorary consultant neurologist at the National Hospital for Neurology and Neurosurgery, Queen Square, where he runs specialist clinics for patients with movement disorders. Dr Barber has particular interests in Parkinson’s disease, atypical Parkinsonian disorders, and treatment of movement disorders with botulinum toxin. He is also a consultant neurologist at London North West University Healthcare NHS Trust, where he manages inpatients and outpatients with all neurological disorders.
Dr Barber studied medicine at Clare College, University of Cambridge and Barts and The London School of Medicine. He undertook postgraduate neurology training through the NIHR clinical academic scheme in Oxford and obtained a DPhil in Biomedical and Clinical Sciences from Brasenose College, University of Oxford, for work studying clinical and neuroimaging characteristics of prodromal neurodegeneration in patients with REM sleep behaviour disorder. His research has been supported by fellowship awards from the Wellcome Trust and the NIHR Oxford Biomedical Research Centre.
Specialties
Research interests
Dr Barber’s research activity has focused on characterising the prodromal phase of Parkinson’s disease and he has published many peer-reviewed papers in this field. He is interested in the neuropsychiatric aspects of prodromal disease and the use of novel neuroimaging biomarkers to detect early neurodegeneration. Dr Barber has also been involved in a number of clinical trials of novel therapeutic agents in Parkinson’s disease and is a member of the Edmund J Safra ACT-PD Consortium (Accelerating Clinical Trials in Parkinson’s Disease).
Publications
Barber TR, Muhammed K, Drew D, et al. Reward insensitivity is associated with dopaminergic deficit in rapid eye movement sleep behaviour disorder. Brain. 2022. doi: 10.1093/brain/awac430
Liu Y, Lawton MA, Lo C, Bowring F, Klein JC, Querejeta-Coma A, Scotton S, Welch J, Razzaque J, Barber T, Ben-Shlomo Y, Hu MT. Longitudinal Changes in Parkinson's Disease Symptoms with and Without Rapid Eye Movement Sleep Behavior Disorder: The Oxford Discovery Cohort Study. Mov Disord. 2021 Aug 26. doi: 10.1002/mds.28763
Lo C, Arora S, Ben-Shlomo Y, Barber TR, Lawton M, Klein JC, Kanavou S, Janzen A, Sittig E, Oertel WH, Grosset D, Hu MT. Olfactory Testing in Parkinson's Disease & REM Behavior Disorder: A Machine Learning Approach. Neurology. 2021 Apr 13;96(15):e2016-e2027. doi: 10.1212/WNL.0000000000011743.
Arnaldi D, Chincarini A, Hu MT, Sonka K, Boeve B, Miyamoto T, Puligheddu M, De Cock VC, Terzaghi M, Plazzi G, Tachibana N, Morbelli S, Rolinski M, Dusek P, Lowe V, Miyamoto M, Figorilli M, Verbizier D, Bossert I, Antelmi E, Meli R, Barber TR, Trnka J, Miyagawa T, Serra A, Pizza F, Bauckneht M, Bradley KM, Zogala D, McGowan DR, Jordan L, Manni R, Nobili F. Dopaminergic imaging and clinical predictors for phenoconversion of REM sleep behaviour disorder. Brain. 2021 Feb 12;144(1):278-287. doi: 10.1093/brain/awaa365
Barber TR, Griffanti L, Bradley KM, McGowan DR, Lo C, Mackay CE, Hu MT, Klein JC. Nigrosome 1 imaging in REM sleep behavior disorder and its association with dopaminergic decline. Ann Clin Transl Neurol. 2020 Jan;7(1):26-35. doi: 10.1002/acn3.50962.
Barber TR and Reading P. Rapid Eye Movement Sleep Behaviour Disorder. Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, 2019. ISBN 9780128093245.
Kelly MJ, Lawton MA, Baig F, Ruffmann C, Barber TR, Lo C, Klein JC, Ben-Shlomo Y, Hu MT. Predictors of motor complications in early Parkinson's disease: A prospective cohort study. Mov Disord. 2019 Aug;34(8):1174-1183. doi: 10.1002/mds.27783
Baig F, Kelly MJ, Lawton MA, Ruffmann C, Rolinski M, Klein JC, Barber T, Lo C, Ben-Shlomo Y, Okai D, Hu MT. Impulse control disorders in Parkinson disease and RBD: A longitudinal study of severity. Neurology. 2019 Aug 13;93(7):e675-e687. doi: 10.1212/WNL.0000000000007942
Postuma RB, Iranzo A, Hu M, Högl B, Boeve BF, Manni R, Oertel WH, Arnulf I, Ferini-Strambi L, Puligheddu M, Antelmi E, Cochen De Cock V, Arnaldi D, Mollenhauer B, Videnovic A, Sonka K, Jung KY, Kunz D, Dauvilliers Y, Provini F, Lewis SJ, Buskova J, Pavlova M, Heidbreder A, Montplaisir JY, Santamaria J, Barber TR, Stefani A, St Louis EK, Terzaghi M, Janzen A, Leu-Semenescu S, Plazzi G, Nobili F, Sixel-Doering F, Dusek P, Bes F, Cortelli P, Ehgoetz Martens K, Gagnon JF, Gaig C, Zucconi M, Trenkwalder C, Gan-Or Z, Lo C, Rolinski M, Mahlknecht P, Holzknecht E, Boeve AR, Teigen LN, Toscano G, Mayer G, Morbelli S, Dawson B, Pelletier A. Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. Brain. 2019 Mar 1;142(3):744-759. doi: 10.1093/brain/awz030
Lo C, Arora S, Baig F, Lawton MA, El Mouden C, Barber TR, Ruffmann C, Klein JC, Brown P, Ben-Shlomo Y, de Vos M, Hu MT. Predicting motor, cognitive & functional impairment in Parkinson's. Ann Clin Transl Neurol. 2019 Aug;6(8):1498-1509. doi: 10.1002/acn3.50853
Barber TR, Griffanti L, Muhammed K, Drew DS, Bradley KM, McGowan DR, Crabbe M, Lo C, Mackay CE, Husain M, Hu MT, Klein JC. Apathy in rapid eye movement sleep behaviour disorder is associated with serotonin depletion in the dorsal raphe nucleus. Brain. 2018 Oct 1;141(10):2848-2854. doi: 10.1093/brain/awy240
Barber TR, Muhammed K, Drew D, Lawton M, Crabbe M, Rolinski M, Quinnell T, Zaiwalla Z, Ben-Shlomo Y, Husain M, Hu MTM. Apathy in rapid eye movement sleep behaviour disorder is common and under-recognized. Eur J Neurol. 2018 Mar;25(3):469-e32. doi: 10.1111/ene.13515
Lawton M, Ben-Shlomo Y, May MT, Baig F, Barber TR, Klein JC, Swallow DMA, Malek N, Grosset KA, Bajaj N, Barker RA, Williams N, Burn DJ, Foltynie T, Morris HR, Wood NW, Grosset DG, Hu MTM. Developing and validating Parkinson's disease subtypes and their motor and cognitive progression. J Neurol Neurosurg Psychiatry. 2018 Dec;89(12):1279-1287. doi: 10.1136/jnnp-2018-318337
Barber TR, Klein JC, Mackay CE, Hu MT. Neuroimaging in pre-motor Parkinson’s disease. Neuroimage Clin. 2017 Apr 21;15:215-227. doi: 10.1016/j.nicl.2017.04.011
Barber TR, Lawton M, Rolinski M, Evetts S, Baig F, Ruffmann C, Gornall A, Klein JC, Lo C, Dennis G, Bandmann O, Quinnell T, Zaiwalla Z, Ben-Shlomo Y, Hu MT. Prodromal Parkinsonism and neurodegenerative risk stratification in REM sleep behaviour disorder. Sleep. 2017 May 4. doi: 10.1093/sleep/zsx071