Photo of Professor Manuel Rodriguez-Justo

Professor Manuel Rodriguez-Justo

Telephone:

Email:

Location:

  • University College Hospital

GMC/GDC number:

6036245

Professional background

Professor Rodriguez-Justo is a consultant in gastrointestinal pathology and haematopathology at UCLH and Professor of Onco-pathology at UCL-Cancer Institute. He trained at Medicine in Madrid (Universidad Autonoma) and completed his specialisation in histopathology in Madrid and Royal Marsden Hospital. Manuel developed his research interest at the Spanish National Cancer Institute (CNIO) and CRUK - Lincoln's Inn Fields (London).

Manuel is also the Pathology Representative in the NCRI – CUP/MUO working party group, Officer at BDIAP (British Division International Academy of Pathology) and BSG (British Society of Gastroenterology) and Pathology professional clinical advisor (PCA) to the NHS-BCSP in London. Professor Rodriguez-Justo is associated editor of Disease of Colon & Rectum and Scientific Reports.

Specialties

Research interests

Manuel has implemented molecular pathways in gastrointestinal cancers, particularly in colorectal cancer and he was the clinical lead at UCLH for the 100K Genomes Project (NHS).

Professor Rodriguez-Justo’s research focuses in tumour hetererogeneity, biomarker signatures, genomic and proteomic target quantification using digital image analysis and profiling. Manuel has published more than 180 peer-reviewed papers, several reviews and book chapters. Manuel has been involved in designing and developing multiple (national and multicentre) trials, acting as pathology lead for most of them.

Publications

Manuel has published more than 200 papers in peer reviewed journals, 1 book, 2 book chapters, 139 conference papers and conference abstracts / presentation slides.  

Most relevant publications: 

  • Rodriguez-Justo, M., Attygalle, A. D., Munson, P., Roncador, G., Marafioti, T., & Piris, M. A. (2009). Angioimmunoblastic T-cell lymphoma with hyperplastic germinal centres: a neoplasia with origin in the outer zone of the germinal centre? Clinicopathological and immunohistochemical study of 10 cases with follicular T-cell markers. MODERN PATHOLOGY, 22(6), 753-761 
  • Guerra, C., Collado, M., Navas, C., Schuhmacher, A. J., Hernandez-Porras, I., Canamero, M., Rodriguez-Justo M, Serrano-M and Barbacid, M. (2011). Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence. CANCER CELL, 19(6), 728-739 
  • Baker, A. -M., Graham, T. A., Elia, G., Wright, N. A., & Rodriguez-Justo, M. (2015). Characterization of LGR5 stem cells in colorectal adenomas and carcinomas. SCIENTIFIC REPORTS, 5, 8 pages. doi:10.1038/srep08654 
  • Cereda, M., Gambardella, G., Benedetti, L., Iannelli, F., Patel, D., Basso, G, . . ., Rodriguez-Justo M, Ciccarelli, F. D. (2016). Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes. NATURE COMMUNICATIONS, 7, 12 
  • Lee, L., Draper, B., Chaplin, N., Philip, B., Chin, M., Galas-Filipowicz, D., Onuoha S, Thomas S, Baldan V. Bughda R, Maciocia P, Kokalaki E, Neves MP, Patel D, Rodriguez-Justo M, Yong K & Pule, M. (2018). An APRIL based chimeric antigen receptor for dual targeting of BCMA and TACI in Multiple Myeloma. BLOOD 15:131(7):746-758  
  • Househam J, Heide T, Cresswell GD, Spiteri I, Kimberley C, Zapata L, Lynn C, James C, Mossner M, Fernandez-Mateos J, Vinceti A, Baker AM, Gabbutt C, Berner A, Schmidt M, Chen B, Lakatos E, Gunasri V, Nichol D, Costa H, Mitchinson M, Ramazzotti D, Werner B, Iorio F, Jansen M, Caravagna G, Barnes CP, Shibata D, Bridgewater J, Rodriguez-Justo M, Magnani L, Sottoriva A, Graham TA. Phenotypic plasticity and genetic control in colorectal cancer evolution. NATURE 2022 Nov;611(7937):744-753 
  • Heide T, Househam J, Cresswell GD, Spiteri I, Lynn C, Mossner M, Kimberley C, Fernandez-Mateos J, Chen B, Zapata L, James C, Barozzi I, Chkhaidze K, Nichol D, Gunasri V, Berner A, Schmidt M, Lakatos E, Baker AM, Costa H, Mitchinson M, Piazza R, Jansen M, Caravagna G, Ramazzotti D, Shibata D, Bridgewater J, Rodriguez-Justo M, Magnani L, Graham TA, Sottoriva A. The co-evolution of the genome and epigenome in colorectal cancer. MATIRE  2022 Nov;611(7937):733-743 
  • Bortolomeazzi M, Keddar MR, Montorsi L, Acha-Sagredo A, Benedetti L, Temelkovski D, Choi S, Petrov N, Todd K, Wai P, Kohl J, Denner T, Nye E, Goldstone R, Ward S, Wilson GA, Al Bakir M, Swanton C, John S, Miles J, Larijani B, Kunene V, Fontana E, Arkenau HT, Parker PJ, Rodriguez-Justo M, Shiu KK, Spencer J, Ciccarelli FD.  Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts. GASTROENTEROLOGY 2021, 161(4):1179-1193 
  • Banks M, Graham D, Jansen M, Gotoda T, Coda S, di Pietro M, Uedo N, Bhandari P, Pritchard DM, Kuipers EJ, Rodriguez-Justo M, Novelli MR, Ragunath K, Shepherd N, Dinis-Ribeiro . British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma. GIT 2019 Sep;68(9):1545-157 
  • Evans JA, Carlotti E, Lin ML, Hackett RJ, Haughey MJ, Passman AM, Dunn L, Elia G, Porter RJ, McLean MH, Hughes F, ChinAleong J, Woodland P, Preston SL, Griffin SM, Lovat L, Rodriguez-Justo M, Huang W, Wright NA, Jansen M, McDonald SAC. Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus. GASTROENTEROLOGY . 2022 Apr;162(4):1197-1209