Professional background
Madhura Castelino is a consultant rheumatologist in adult rheumatology at University College Hospital (UCH) and honorary clinical lecturer at University College London. She leads the clinical trials, spondyloarthritis service and biologics service for the Rheumatology Department and is the divisional audit lead for Medical Specialties at UCH. She has professional interest in the pathogenesis and management of inflammatory arthritis especially spondyloarthritis (psoriatic arthritis and axial spondyloarthritis), musculoskeletal imaging and clinical photoacoustic imaging. She is an experienced principal investigator in several clinical studies including commercial and non-commercial trials at UCH.
Her research interests include the role of the microbiome in inflammatory arthritis especially spondyloarthritis, patient related outcomes in chronic disease and imaging in inflammatory arthritis. She has established the UCL Rheumatology Patient Partners, a patient public involvement and engagement initiative to support patient focussed research.
She is the deputy clinical academic lead for UCLH in the UK Musculoskeletal Translational Research Collaboration. She has contributed to the UK GCA consortium and OUTPASS Study Syndicate. Madhura completed her initial medical training at Manipal University, India and clinical training in rheumatology in the North West Deanery, Manchester, U.K.
She also holds an MSc in Clinical Rheumatology (2011) and a PhD in Rheumatology (2016) on the microbiome in psoriatic arthritis from the University of Manchester.
Specialties
Research interests
- Spondyloarthritis: psoriatic arthritis and ankylosing spondylitis (axial spondyloarthritis)
- Clinical imaging
- Microbiome in inflammatory arthritis
- Delivery of clinical trials
Languages spoken
Hindi, Kannada, Konkani
Publications
- Quantitative magnetic resonance imaging (qMRI) in axial spondyloarthritis. Thorley N, Jones A, Ciurtin C, Castelino M, Bainbridge A, Abbasi M, Taylor S, Zhang H, Hall-Craggs MA, Bray TJP.Br J Radiol. 2023 Mar 1;96(1144):20220675. doi: 10.1259/bjr.20220675. Epub 2023 Jan 25.PMID: 36607267
- The influence of deprivation in the outcomes of psoriatic arthritis within the UK-utilizing Outcomes of Treatment in Psoriatic Arthritis Study Syndicate (OUTPASS) data. Lyon M, Zhao SS, Jani M, Chinoy H, Barton A, Bluett J; OUTPASS Study Syndicate.Rheumatol Adv Pract. 2024 May 2;8(2):rkae051. doi: 10.1093/rap/rkae051. eCollection 2024.PMID: 38721964
- Psoriatic arthritis: the role of self-reported non-adherence, non-trough drug levels, immunogenicity and conventional synthetic DMARD co-therapy in adalimumab and etanercept response. Curry PDK, Morris AP, Jani M, Chinoy H, Barton A, Bluett J; OUTPASS Collaborators.Rheumatol Adv Pract. 2024 Jan 30;8(1):rkae014. doi: 10.1093/rap/rkae014. eCollection 2024.PMID: 38415954 Free PMC article.
- A review of a strategic roadmapping exercise to advance clinical translation of photoacoustic imaging: From current barriers to future adoption. Assi H, Cao R, Castelino M, Cox B, Gilbert FJ, Gröhl J, Gurusamy K, Hacker L, Ivory AM, Joseph J, Knieling F, Leahy MJ, Lilaj L, Manohar S, Meglinski I, Moran C, Murray A, Oraevsky AA, Pagel MD, Pramanik M, Raymond J, Singh MKA, Vogt WC, Wang L, Yang S, Members Of Ipasc, Bohndiek SE.Photoacoustics. 2023 Aug 2;32:100539. doi: 10.1016/j.pacs.2023.100539. eCollection 2023 Aug.PMID: 37600964 Free PMC article. Review.
- Patient and public involvement in rheumatology research: embracing the wave of change. Yeoh SA, Burke B, Castelino M, Hyndman T, Keenan AM, Watson S, Coates LC.Lancet Rheumatol. 2021 Aug;3(8):e540-e542. doi: 10.1016/S2665-9913(21)00184-3.PMID: 38287615 No abstract available.
- Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study. Borrego-Yaniz G, Ortiz-Fernández L, Madrid-Paredes A, Kerick M, Hernández-Rodríguez J, Mackie SL, Vaglio A, Castañeda S, Solans R, Mestre-Torres J, Khalidi N, Langford CA, Ytterberg S, Beretta L, Govoni M, Emmi G, Cimmino MA, Witte T, Neumann T, Holle J, Schönau V, Pugnet G, Papo T, Haroche J, Mahr A, Mouthon L, Molberg Ø, Diamantopoulos AP, Voskuyl A, Daikeler T, Berger CT, Molloy ES, Blockmans D, van Sleen Y, Iles M, Sorensen L, Luqmani R, Reynolds G, Bukhari M, Bhagat S, Ortego-Centeno N, Brouwer E, Lamprecht P, Klapa S, Salvarani C, Merkel PA, Cid MC, González-Gay MA, Morgan AW, Martin J, Márquez A; Spanish GCA Group; UK GCA Consortium; Vasculitis Clinical Research Consortium.Lancet Rheumatol. 2024 Jun;6(6):e374-e383. doi: 10.1016/S2665-9913(24)00064-X. Epub 2024 May 8.PMID: 38734017 Free PMC article.
- Multi-Omic Biomarkers for Patient Stratification in Sjogren's Syndrome-A Review of the Literature. Martin-Gutierrez L, Wilson R, Castelino M, Jury EC, Ciurtin C.Biomedicines. 2022 Jul 22;10(8):1773. doi: 10.3390/biomedicines10081773.PMID: 35892673 Free PMC article. Review.
- Increased erythrocyte mean corpuscular volume by methotrexate predicts clinical response in psoriatic arthritis. Shipa MRA, Langley L, Sacks B, Yeoh SA, Mainuddin MD, Mukerjee D, Castelino M, Ehrenstein MR.Rheumatology (Oxford). 2022 Aug 30;61(9):e270-e273. doi: 10.1093/rheumatology/keac276.PMID: 35532065 Free PMC article. No abstract available.
- Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease-associated psychological morbidity. Bain KA, McDonald E, Moffat F, Tutino M, Castelino M, Barton A, Cavanagh J, Ijaz UZ, Siebert S, McInnes IB, Astrand A, Holmes S, Milling SWF.Br J Dermatol. 2020 Jan;182(1):130-137. doi: 10.1111/bjd.18008. Epub 2019 Jul 17.PMID: 30980732 Free article.
- Optimisation of methods for bacterial skin microbiome investigation: primer selection and comparison of the 454 versus MiSeq platform. Castelino M, Eyre S, Moat J, Fox G, Martin P, Ho P, Upton M, Barton A.BMC Microbiol. 2017 Jan 21;17(1):23. doi: 10.1186/s12866-017-0927-4.PMID: 28109256 Free PMC article.
- Association Between Genetic Variation in FOXO3 and Reductions in Inflammation and Disease Activity in Inflammatory Polyarthritis. Viatte S, Lee JC, Fu B, Espéli M, Lunt M, De Wolf JN, Wheeler L, Reynolds JA, Castelino M, Symmons DP, Lyons PA, Barton A, Smith KG.Arthritis Rheumatol. 2016 Nov;68(11):2629-2636. doi: 10.1002/art.39760.PMID: 27214848 Free PMC article.
- The skin microbiome in psoriatic arthritis: methodology development and pilot data. Castelino M, Eyre S, Moat J, Fox G, Martin P, Ijaz U, Quince C, Ho P, Upton M, Barton A.Lancet. 2015 Feb 26;385 Suppl 1:S27. doi: 10.1016/S0140-6736(15)60342-7.PMID: 26312849
- The bacterial skin microbiome in psoriatic arthritis, an unexplored link in pathogenesis: challenges and opportunities offered by recent technological advances. Castelino M, Eyre S, Upton M, Ho P, Barton A.Rheumatology (Oxford). 2014 May;53(5):777-84. doi: 10.1093/rheumatology/ket319. Epub 2013 Sep 24.PMID: 24067887 Review.
- Comparison of the psychometric properties of health-related quality of life measures used in adults with systemic lupus erythematosus: a review of the literature. Castelino M, Abbott J, McElhone K, Teh LS.Rheumatology (Oxford). 2013 Apr;52(4):684-96. doi: 10.1093/rheumatology/kes370. Epub 2012 Dec 22.PMID: 23264550 Review.
- The LupusQoL and associations with demographics and clinical measurements in patients with systemic lupus erythematosus. McElhone K, Castelino M, Abbott J, Bruce IN, Ahmad Y, Shelmerdine J, Peers K, Isenberg D, Ferenkeh-Koroma A, Griffiths B, Akil M, Maddison P, Gordon C, Teh LS.J Rheumatol. 2010 Nov;37(11):2273-9. doi: 10.3899/jrheum.091277. Epub 2010 Sep 1.PMID: 20810500
- Genetic susceptibility factors for psoriatic arthritis. Castelino M, Barton A.Curr Opin Rheumatol. 2010 Mar;22(2):152-6. doi:10.1097/BOR.0b013e32833669d2.PMID: 20084005 Review.
- Wegener's granulomatosis in pregnancy: a case report and review of the medical literature. Devakumar VN, Castelino M, Chow SC, Teh LS.BMJ Case Rep. 2010;2010:bcr09.2009.2296. doi: 10.1136/bcr.09.2009.2296. Epub 2010 Jan 13.PMID: 22242076 Free PMC article.