Photo of Dr Jahanzaib Khwaja

Dr Jahanzaib Khwaja

Email:

Location:

  • University College Hospital

GMC/GDC number:

7419416

Professional background

Dr Jahanzaib Khwaja is a consultant haematologist specialising in Waldenström macroglobulinemia, IgM related disorders and amyloidosis at University College London Hospital and the National Amyloidosis Centre, Royal Free. He graduated from Imperial College London and undertook postgraduate training in London.

He is an active member of the British Society of Haematology, sitting on a number of committees and has contributed to national and international guidelines.

Specialties

Research interests

  • Clinical trials and collaboration with international research groups.  
  • UCL academic reviewer for research low-risk ethics 

Publications

  • Khwaja J, Ravichandran S, Cohen O, Foard D, Martinez-Naharro A, Venneri L, Whelan C, Hawkins PN, Gillmore J, Lachmann HJ, Mahmood S, Fontana M, Wechalekar A. Ethnicity in systemic AL amyloidosis may impact risk stratification. Haematologica. 2025 Jan 16. 
  • Jamroziak K, Zielonka K, Khwaja J, Wechalekar AD. Update on B-cell maturation antigen-directed therapies in AL amyloidosis. Br J Haematol. 2025 Jan 2. doi: 10.1111/bjh.19960. 
  • Durot E, Kanagaratnam L, Zanwar S, Kaufman A, D'Sa S, Toussaint E, Roos-Weil D, Alcoceba M, Vos JMI, Michallet AS, Talaulikar D, Kastritis E, Khwaja J, Treon SP, Garcia-Sanz R, Morel P, Munoz J, Castillo JJ, Kapoor P, Delmer A. Autologous and Allogeneic Stem-Cell Transplantation for Transformed Waldenström Macroglobulinemia. Am J Hematol. 2024 Nov 26. doi: 10.1002/ajh.27543 
  • Khwaja J, Ravichandran S, Bomsztyk J, Cohen O, Foard D, Martinez-Naharro A, Venneri L, Fontana M, Whelan C, Hawkins PN, Gillmore JD, Lachmann HJ, Mahmood S, Wechalekar A. Refining prognostication in systemic AL amyloidosis: limited value of dFLC. Amyloid. 2024 Sep 23:1-3. doi: 10.1080/13506129.2024.2406845. Epub ahead of print. PMID: 39311543. 
  • Khwaja J, Japzon N, Gabriel M, Tomkins O, Lindsay J, Kyriakou C, Wechalekar A, D'Sa S. Ethnic diversity in presentation and outcome of Waldenström macroglobulinemia and IgM monoclonal gammopathy of clinical significance in the United Kingdom. Haematologica. 2024 Jun 6. doi: 10.3324/haematol.2024.285420. Epub ahead of print. PMID: 38841793. 
  • Bomsztyk J, Ravichandran S, Khwaja J, Cohen O, Rauf MU, Foard D, et al. Response rates to second-line treatment with daratumumab bortezomib dexamethasone (DVD) in relapsed/refractory light chain amyloidosis (AL) after initial Bortezomib-based regime. Br J Haematol. 2024;00:1–8. https://doi.org/10.1111/bjh.19529 
  • Jalink M, Jacobs CF Dr, Khwaja J, Evers D, Bruggeman C, Fattizzo B, Michel M, Crickx E, Hill QAA, Jaeger U, Kater AP, Mäkelburg ABU, Breedijk A, Te Boekhorst PAWT, Hoeks MPA, de Haas M, D'Sa SP, Vos JMIMI. Daratumumab monotherapy in refractory warm autoimmune hemolytic anemia and cold agglutinin disease. Blood Adv. 2024 Mar 20:bloodadvances.2024012585. doi: 10.1182/bloodadvances.2024012585. Epub ahead of print. 
  • Khwaja J, Ravichandran S, Bomsztyk J, Cohen O, Foard D, Martinez-Naharro A, Venneri L, Fontana M, Hawkins PN, Gillmore J, Lachmann HJ, Mahmood S, Whelan C, Kirkwood AA, Wechalekar A. Limited utility of Mayo 2012 cardiac staging system for risk stratification of patients with advanced cardiac AL amyloidosis - analysis of a uniformly treated cohort of 1,275 patients. Haematologica. 2024 Jan 11. doi: 10.3324/haematol.2023.284348. Epub ahead of print. 
  • Bomsztyk J, Ravichandran S, Giles HV Dr, Wright NJ, Berlanga O, Khwaja J, Mahmood S, Wisniowski B, Cohen OC, Foard D, Gilbertson J, Rauf MU, Starr N, Martinez-Naharro A, Venneri L, Whelan C, Fontana M, Hawkins PN, Gillmore JD, Lachmann HJ, Harding S, Pratt G, Wechalekar AD. Complete responses in AL amyloidosis are unequal - the impact of free light chain mass spectrometry in AL amyloidosis. Blood. 2024 Jan 9:blood.2023022399. doi: 10.1182/blood.2023022399. Epub ahead of print. 
  • Khwaja J, Bomsztyk J, Atta M, Bygrave C, Forbes A, Durairaj S, Fernandes S, Taylor J, Paterson P, Brearton G, Crawley C, Sheehy O, Brown R, Soutar R, Garg M, Rydzewski A, Jamroziak K, Mahmood S, Wechalekar AD. Real-world efficacy of single-agent belantamab mafodotin in relapsed systemic AL amyloidosis. Br J Haematol. 2024 Jan 3. doi: 10.1111/bjh.19286. 
  • Khwaja J, Vos JMI, Pluimers TE, Japzon N, Patel A, Salter S, Kwakernaak AJ, Gupta R, Rismani A, Kyriakou C, Wechalekar AD, D'Sa S. Clinical and clonal characteristics of monoclonal immunoglobulin M-associated type I cryoglobulinaemia. Br J Haematol. 2024 Jan;204(1):177-185. doi: 10.1111/bjh.19112. Epub 2023 Sep 19. PMID: 37726004. 
  • Khwaja J, Nayak L, Cwynarski K. Evidence-based management of primary and secondary CNS lymphoma. Semin Hematol. 2023 Dec 1:S0037-1963(23)00090-2. doi: 10.1053/j.seminhematol.2023.11.003. Epub ahead of print.  
  • Wilson MR, Kirkwood AA, Wong Doo N, Soussain C, Choquet S, Lees C, Fox C, Preston G, Ahearne M, Strüßmann T, Clavert A, Rusconi C, Ku M, Khwaja J, Narkhede M, Lewis K, Durot E, Smith J, Renaud L, Ferreri AJM, El-Galaly T, Cwynarski K, McKay P, Eyre TA. Dosage of high-dose methotrexate as CNS prophylaxis in DLBCL: A detailed analysis of toxicity and impact on CNS relapse. Am J Hematol. 2023 Nov 30. doi: 10.1002/ajh.27167 
  • Khwaja J, Japzon N, Gabriel M, Raju K, Rajaratnam V, Gupta R, Rismani A, Kyriakou C, D'Sa S. Cold agglutinin disease and cryoglobulinaemia: A frequent coexistence with clinical impact. Br J Haematol. 2023 Nov 3. 
  • Lewis K, Jakobsen L, Villa D, Smedby K, Savage K, Eyre T, Cwynarski K, Bishton M, Fox C, Hawkes E, Maurer M, El-Galaly T, Cheah C, Bobillo, Caporn P, Van Zyl J, Klanova M, Trněny M, Puckrin R, Stewart D, Tun A, Thanarajasingam G, Nair R, Nastoupil L, Djebbari F, Joffe E, Eloranta S, Harrysson S, Sehn L, Maliske S, Poonsombudlert K, Guo X, Hapgood G, Manos K, Khwaja J, Minson A, Dickinson M, Øvlisen A, Gregory G, Gilbertson M, Streit I, Scott H, Ku M, de Mel S, Ying Yong K, Xin L, Mokoonlall M, Talaulikar D, Hamad N, Srinivasan S, McVilly N, Johnston A, Brunner M, Pophali P High-Dose Methotrexate as CNS Prophylaxis in High-Risk Aggressive B-Cell Lymphoma. J Clin Oncol. 2023 Oct 5:JCO2300365. doi: 10.1200/JCO.23.00365. 
  • Khwaja J, Vos JMI, Pluimers TE, Japzon N, Patel A, Salter S, Kwakernaak AJ, Gupta R, Rismani A, Kyriakou C, Wechalekar AD, D'Sa S. Clinical and clonal characteristics of monoclonal immunoglobulin M-associated type I cryoglobulinaemia. Br J Haematol. 2023 Sep 19. doi: 10.1111/bjh.19112 
  • Khwaja J, Salter SJ, D’Sa S. IgM-Associated Cryoglobulinaemia. Hemato. 2023; 4(3):240-249. https://doi.org/10.3390/hemato4030019 
  • Khwaja J, Cwynarski K. Management of primary and secondary CNS lymphoma. Hematol Oncol. 2023 Jun;41 Suppl 1:25-35. doi: 10.1002/hon.3148 
  • Bristogiannis S, Khwaja J, Lwin Y, Uppal E, D’Sa S, Kyriakou C. Systematic Literature Review of Quality of Life Questionnaires in Waldenström macroglobulinaemia- Need for a disease-specific tool. eJHaem. 2023 Mar 21;4(2):555-558. doi: 10.1002/jha2.668. 
  • Bristogiannis S, Khwaja J, Lwin Y, Wechelaker A, Wisniowski B, Mahmood AS, Sachchithanantham S, Kyriakou C. Is there a representative quality-of-life questionnaire for patients with AL amyloidosis?-systematic literature review. Br J Haematol. 2023 May 16. doi: 10.1111/bjh.18860 
  • El-Sharkawi D, Sud A, Prodger C, Khwaja J, Shotton R, Hanley B, Peacock V, Peng YY, Arasaretnam A, Sharma S, Aldridge F, Sharma B, Wotherspoon A, Cheung B, De Lord C, Johnston R, Kassam S, Pettengel R, Linton K, Greaves P, Cook L, Naresh KN, Cwynarski K, Eyre TA, Chau I, Cunningham D, Iyengar S. A retrospective study of MYC rearranged diffuse large B-cell lymphoma in the context of the new WHO and ICC classifications. Blood Cancer J. 2023 Apr 18;13(1):54. doi: 10.1038/s41408-023-00827-5 
  • Khwaja J, Uppal E, Bristogiannis S, McCarthy H, Kothari J, Rismani A, Scorer H, Nicholson J, El-Sharkawi D, D'Sa S, Kyriakou C. Patient reported outcome measures in Waldenström macroglobulinaemia: A real-world data analysis from the WMUK Rory Morrison Registry. EJHaem. 2022 Dec 29;4(1):221-225. doi: 10.1002/jha2.640 
  • Uppal E, Khwaja J, Bomsztyk J, McCarthy H, Kothari J, Walton P, Scorer H, Kyriakou C, El-Sharkawi D, D'Sa S. The Rory Morrison WMUK Registry for Waldenström macroglobulinaemia: The growth of a national registry for a rare disorder. Br J Haematol. 2023 Jun;201(5):905-912. doi: 10.1111/bjh.18680 
  • Khwaja J, Uppal E, Baker R, Trivedi K, Rismani A, Gupta R, Proctor I, Kyriakou C, D'Sa S. Bortezomib-based therapy is effective and well tolerated in frontline and multiply pre-treated Waldenström macroglobulinaemia including BTKi failures: A real-world analysis. EJHaem. 2022 Oct 20;3(4):1330-1334. doi: 10.1002/jha2.597. 
  • Bobillo S, Khwaja J, Ferreri AJ, Cwynarski K. Prevention and management of secondary central nervous system lymphoma. Haematologica. 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457 
  • D'Sa S, Khwaja J, Keddie S, Keh RY, Smyth D, Ronneberger R, Dubash S, Sivabalasingham S, Wan S, Hoskote C, Baldeweg S, Sive J, Lunn MP. Comprehensive Diagnosis and Management of POEMS Syndrome. Hemasphere. 2022 Oct 31;6(11):e796. doi: 10.1097/HS9.0000000000000796. PMID: 36340912 
  • Khwaja J, Kirkwood AA, Isbell LK, Steffanoni S, Goradia H, Pospiech L, Fail T, Nicholson E, Fletcher K, Linton KM, Parsons KE, Elmusharaf N, Eccersley L, Eyre TA, Chaganti S, Smith J, Thakrar N, Kutilina A, Calimeri T, Martinez-Calle N, El-Sharkawi D, Osborne W, Illerhaus G, Fox CP, Ferreri AJM, Schorb E, Cwynarski K. International multicenter retrospective analysis of thiotepa-based autologous stem cell transplantation for secondary central nervous system lymphoma. Haematologica. 2023 Mar 1;108(3):882-888. doi: 10.3324/haematol.2022.281640 
  • Khwaja J, Bomsztyk J, Mahmood S, Wisniowski B, Shah R, Tailor A, Yong K, Popat R, Rabin N, Kyriakou C, Sive J, Esposti SD, Larkin DFP, Worthington S, Hart A, Dowling E, Correia N, Bygrave C, Rydzewski A, Jamroziak K, Wechalekar AD. High response rates with single-agent belantamab mafodotin in relapsed systemic AL amyloidosis. Blood Cancer J. 2022 Sep 5;12(9):128. doi: 10.1038/s41408-022-00717-2. PMID: 36064540. 
  • Khwaja J, Keh R, Smyth D, Lunn MP, D'Sa S, Sive J. Daratumumab-bortezomib-dexamethasone use in relapsed POEMS syndrome. EJHaem. 2022 Jun 5;3(3):1021-1024 
  • Bomsztyk J, Khwaja J, Wechalekar AD. Recent guidelines for high-dose chemotherapy and autologous stem cell transplant for systemic AL amyloidosis: a practitioner's perspective. Expert Rev Hematol. 2022 Sep;15(9):781-788. doi: 10.1080/17474086.2022.2115353. 
  • Khwaja J, D'Sa S, Lunn MP, Sive J. Evidence-based medical treatment of POEMS syndrome. Br J Haematol. 2023 Jan;200(2):128-136 
  • Khwaja J, D'Sa S, Minnema MC, Kersten MJ, Wechalekar A, Vos JM. IgM monoclonal gammopathies of clinical significance: diagnosis and management. Haematologica. 2022 Sep 1;107(9):2037-2050. doi: 10.3324/haematol.2022.280953 
  • Wilson MR, Eyre TA, Kirkwood AA, Wong Doo N, Soussain C, Choquet S, Martinez-Calle N, Preston G, Ahearne MJ, Schorb E, Moles-Moreau MP, Ku M, Rusconi C, Khwaja J, Narkhede M, Lewis KL, Calimeri T, Durot E, Renaud L, Øvlisen AK, Mcilroy G, Ebsworth TJ, Elliot J, Santarsieri A, Ricard L, Shah N, Liu Q, Zayac AS, Vassallo F, Lebras L, Roulin L, Lombion N, Manos K, Fernandez R, Hamad N, Lopez-Garcia A, O'Mahony D, Gounder P, Forgeard N, Lees C, Agbetiafa K, Strüessmann T, Htut TW, Clavert A, Scott H, Guidetti A, Barlow BR, Tchernonog E, Smith J, Miall F, Fox CP, Cheah CY, El Galaly TC, Ferreri AJM, Cwynarski K, McKay P. Timing of high dose methotrexate CNS prophylaxis in DLBCL: a multicenter international analysis of 1,384 patients. Blood. 2022 Jan 7:blood.2021014506. 
  • Khwaja J, Burns JE, Ahmed N, Cwynarski K. HIV-associated lymphoma—advances in clinical management. Annals of Lymphoma; Vol 5 (September 2021): Annals of Lymphoma. 2021 
  • Martinez-Calle N, Kirkwood A, Lamb, Smith A, Khwaja J, Manos K, Shrubsole C, Gray N, Lewis K, Tivey A, Bishton M, Hawkes E, Ahearne M, Osborne W, Collins G, Illidge T, Linton K, Cwynarski K, Burton C, Fox CP Systemic ALCL Treated in Routine Clinical Practice: Outcomes Following First-Line Chemotherapy from a Multicentre Cohort. Adv Ther. 2021 Jul;38(7):3789-3802.  
  • Ferreri AJM, Doorduijn JK, Re A, Cabras MG, Smith J, Ilariucci F, Luppi M, Calimeri T, Cattaneo C, Khwaja J, Botto B, Cellini C, Nassi L, Linton K, McKay P, Olivieri J, Patti C, Re F, Fanni A, Singh V, Bromberg JEC, Cozens K, Gastaldi E, Bernardi M, Cascavilla N, Davies A, Fox CP, Frezzato M, Osborne W, Liberati AM, Novak U, Zambello R, Zucca E, Cwynarski K; International Extranodal Lymphoma Study Group (IELSG). MATRix-RICE therapy and autologous haematopoietic stem-cell transplantation in diffuse large B-cell lymphoma with secondary CNS involvement (MARIETTA): an international, single-arm, phase 2 trial. Lancet Haematol. 2021 Feb;8(2):e110-e121.  
  • Cwynarski K, Khwaja J, Montoto S. 'CARMEN': is less, more? Lessons from trials in human immunodeficiency virus-Burkitt lymphoma (HIV-BL). Br J Haematol. 2020 Oct 22.  
  • Wilson MR, Eyre TA, Martinez-Calle N, Ahearne M, Parsons KE, Preston G, Khwaja J, Schofield J, Elliot J, Mula Kh A, Shah N, Cheung CK, Timmins MA, Creasey T, Linton K, Smith J, Fox CP, Miall F, Cwynarski K, McKay P. Timing of high-dose methotrexate CNS prophylaxis in DLBCL: an analysis of toxicity and impact on R-CHOP delivery. Blood Adv. 2020 Aug 11;4(15):3586-3593.  
  • Gulati A, Japp AG, Raza S, Halliday BP, Jones DA, Newsome S, Ismail NA, Morarji K, Khwaja J, Spath N, Shakespeare C, Kalra PR, Lloyd G, Mathur A, Cleland JGF, Cowie MR, Assomull RG, Pennell DJ, Ismail TF, Prasad SK. Absence of Myocardial Fibrosis Predicts Favorable Long-Term Survival in New-Onset Heart Failure. Circ Cardiovasc Imaging. 2018 Sep;11(9):e007722.  
  • Khwaja J. Bilateral adrenal hemorrhage in the background of Escherichia coli sepsis: a case report. J Med Case Rep. 2017 Mar 17;11(1):72.  
  • Ismail TF, Jabbour A, Gulati A, Mallorie A, Raza S, Cowling TE, Das B, Khwaja J, Alpendurada FD, Wage R, Roughton M, McKenna WJ, Moon JC, Varnava A, Shakespeare C, Cowie MR, Cook SA, Elliott P, O'Hanlon R, Pennell DJ, Prasad SK. Role of late gadolinium enhancement cardiovascular magnetic resonance in the risk stratification of hypertrophic cardiomyopathy. Heart. 2014 Dec;100(23):1851-8.  
  • Gulati A, Ismail TF, Jabbour A, Alpendurada F, Guha K, Ismail NA, Raza S, Khwaja J, Brown TD, Morarji K, Liodakis E, Roughton M, Wage R, Pakrashi TC, Sharma R, Carpenter JP, Cook SA, Cowie MR, Assomull RG, Pennell DJ, Prasad SK. The prevalence and prognostic significance of right ventricular systolic dysfunction in nonischemic dilated cardiomyopathy. Circulation. 2013 Oct 8;128(15):1623-33.  
  • Gulati A, Ismail TF, Jabbour A, Ismail NA, Morarji K, Ali A, Raza S, Khwaja J, Brown TD, Liodakis E, Baksi AJ, Shakur R, Guha K, Roughton M Wage R, Cook SA, Alpendurada F, Assomull RG, Mohiaddin RH, Cowie MR, Pennell DJ, Prasad SK. Clinical utility and prognostic value of left atrial volume assessment by cardiovascular magnetic resonance in non-ischaemic dilated cardiomyopathy. Eur J Heart Fail. 2013 Jun;15(6):660-70.  
  • Gulati A, Jabbour A, Ismail TF, Guha K, Khwaja J, Raza S, Morarji K, Brown TD, Ismail NA, Dweck MR, Di Pietro E, Roughton M, Wage R, Daryani Y, O'Hanlon R, Sheppard MN, Alpendurada F, Lyon AR, Cook SA, Cowie MR, Assomull RG, Pennell DJ, Prasad SK. Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy. JAMA. 2013 Mar 6;309(9):896-908.