Dr Asma Fikree

Rectal hyposensitivity: a common pathophysiological finding in patients with constipation and associated hypermobile Ehlers-Danlos syndrome. 

Choudhary A, Vollebregt PF, Aziz Q, Scott SM, Fikree A  Aliment Pharmacol Ther. 2022 Sep;56(5):802-813.  

Overlap between irritable bowel syndrome and hypermobile Ehlers-Danlos syndrome: An unexplored clinical phenotype? Choudhary A, Fikree A, Aziz Q.  Am J Med Genet C Semin Med Genet. 2021 Dec;187(4):561-569.

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation. 

Scott SM, Simrén M, Farmer AD, Dinning PG, Carrington EV, Benninga MA, Burgell RE, Dimidi E, Fikree A, Ford AC, Fox M, Hoad CL, Knowles CH, Krogh K, Nugent K, Remes-Troche JM, Whelan K, Corsetti M.  Neurogastroenterol Motil. 2021 Jun;33(6): e14050 

Impact of joint hypermobility syndrome on gastric accommodation and nutrient tolerance in functional dyspepsia. Carbone F, Goelen N, Fikree A, Aziz Q, Tack J.  

Neurogastroenterol Motil. 2021 Jul;33(7): e14086.  

Joint Hypermobility Syndrome in Patients with Functional Dyspepsia. Carbone F, Fikree A, Aziz Q, Tack J.  Clin Transl Gastroenterol. 2020 Nov;11(11): e00220 

Colonoscopy is safe and not associated with higher pain scores in patients with hypermobility spectrum disorder: results from an exploratory prospective study.  Beckers AB, Vork L, Fikree A, de Ridder R, Aziz Q, Masclee A, Keszthelyi D.  Therap Adv Gastroenterol. 2020 Jul 17;13:1756284820927310 

Rumination syndrome: Assessment of vagal tone during and after meals and during diaphragmatic breathing  Hoshikawa Y, Fitzke H, Sweis R, Fikree A, Saverymuttu S, Kadirkamanathan S, Iwakiri K, Yazaki E, Aziz Q, Sifrim D.  Neurogastroenterol Motil. 2020 Nov;32(11): e13873 

Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance 

Nakagawa K, Hara K, Fikree A, Siddiqi S, Woodland P, Masamune A, Aziz Q, Sifrim D, Yazaki E.J  

J Gastroenterol. 2020 Mar;55(3):273-280 

Gastrointestinal involvement in the Ehlers-Danlos syndromes. Fikree A, Chelimsky G, Collins H, Kovacic K, Aziz Q.  Am J Med Genet C Semin Med Genet. 2017 Mar;175(1):181-187.  

Gastrointestinal disorders in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type: A review for the gastroenterologist.  

Beckers AB, Keszthelyi D, Fikree A, Vork L, Masclee A, Farmer AD, Aziz Q. Neurogastroenterol Motil. 2017 Aug;29(8).  

The association between Ehlers-Danlos Syndrome – Hypermobility Type and Gastrointestinal Symptoms in University Students: a cross-sectional study  

A Fikree, R Aktar, J K Morris, R Grahame, C H Knowles, Q Aziz Neurogastroenterol Motil. 2016 Sep 28. doi: 10.1111/nmo.12942. [Epub ahead of print] 

Comparative quantitative assessment of global small bowel motility using magnetic resonance imaging in chronic intestinal pseudo-obstruction and healthy controls. 

Menys A, Butt S, Emmanuel A, Plumb AA, Fikree A, Knowles C, Atkinson D, Zarate N, Halligan S, Taylor SA. 

Neurogastroenterol Motil. 2015 Dec 10. doi: 10.1111/nmo.12735. [Epub ahead of print] 

Functional gastrointestinal disorders are associated with the joint hypermobility syndrome in secondary care: a case-control study. A Fikree, R Aktar, R Grahame, A J Hakim, J K Morris, C H Knowles, Q Aziz. Neurogastroenterol Motil. 2015: 27: 569-579 

A prospective evaluation of undiagnosed joint hypermobility syndrome in patients with gastrointestinal symptoms. A Fikree, R Grahame, R Aktar, A Farmer, Alan J Hakim, Joan K Morris, C.H.Knowles, Q Aziz. Clinical Gastroenterology and Hepatology, 2014 Oct;12(10):1680-87  

Addressing the confounding role of joint hypermobility syndrome and gastrointestinal involvement in postural tachycardia syndrome. Farmer AD, Fikree A, Aziz Q. Clin Auton Res, 2014 Jun;24(3):157-8. 

Fever, ulcers and joint pain: an incidental finding of oesophageal dysmotility.  Anwuzia-Iwegbu C, Fikree A, Tufton N. BMJ Case Rep. 2013 Aug 29;2013. pii: bcr2013200047. doi: 10.1136/bcr-2013-200047. 

An unusual case of colonic lymphoid nodular hyperplasia in an adolescent patient. Vossenkämper A, Fikree A, Fairclough PD, Aziz Q, MacDonald TT . J Pediatr Gastroenterol Nutr. 2011 Dec;53(6):684-6. doi: 10.1097/MPG.0b013e318223650a 

Invited articles: 

Gastrointestinal symptoms and nutritional issues in patients with hypermobility disorders: assessment, diagnosis and management. Lam C, Amarasinghe G, Zarate-Lopez N, Fikree A, Byrne P, Kiani – Alikhan S, Gabe, S, Paine P. Frontline Gastroenterology, Published Online First: 08 June 2022.  

Editorial: rectal hyposensitivity in patients with hypermobile Ehlers-Danlos syndrome and constipation-authors' reply. Fikree A, Vollebregt PF, Choudhary A, Aziz Q, Scott SM.  

Aliment Pharmacol Ther. 2022 Sep;56(5):907-908.  

Mistakes in Gastroparesis and How to Avoid them. A Fikree UEG 2021 

Management of functional gastrointestinal disorders.  Fikree A, Byrne P.  Clin Med (Lond). 2021 Jan;21(1):44-52 

Scleroderma and other connective tissue disorders. A Fikree Medicine, 2019 July; 47(7) :460-465 

Joint Hypermobility Syndrome. A Fikree, A; Aziz, Q; Grahame, R. Rheum Dis Clin North Am. 2013 May;39(2):419-30. doi: 10.1016/j.rdc.2013.03.003. 

Book chapters: 

Postural Tachycardia Syndrome and the gut. A Green, A Fikree In: Postural Tachycardia Syndrome: A concise and practical guide to management and associated conditions: Springer Nature Publishing. 

Ehlers Danlos Syndrome and Marfan Syndrome. Hakim AJ, Fikree A. In: R. A. Watts, Watts, Scott DGI, editors. Landmark Papers in Rheumatology: Oxford University Press; 2015. ISBN: 978-0-19-968837-1 

Small Bowel. A Fikree. In: M. A. Choudry and M. Winslet, editors.  Oxford Handbook of Surgical Oncology: Oxford University Press; 2007