Professional background

Associate Professor and Honorary Consultant in Infectious Diseases/Microbiology at UCL and UCLH. 

Research interests

The immune response to paediatric and adult infections to inform development of novel diagnostics and therapeutics.

Publications

2024     Identifying immune signatures of sepsis in very preterm babies. Das et al. Nature Communications
2024     Early dynamic changes to monocytes following major surgery are associated with subsequent infections. T Snow, A Waller, R Loye, F Ryckaert, A Cesar, N Saleem, R Roy, J Whittle, A Al-Hindawi, A Das, M Singer, D Brealey, N Arulkumaran. Frontiers in Immunology. 
2024     Evaluating probiotic mechanisms may help inform optimum strain selection for use in clinical trials. A Das and P Fleming. Pediatric Research. Manuscript, under review, minor revisions) 
2022     Activation of Lymphocytes in Healthy Neonates Within Hours of Birth. G Ariyakumar, S Gee, A Das, Shraddha Kamdar, Rachel Tribe, Deena L Gibbons. Frontiers in Immunology. 
2022     Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19. M Joseph, Y Wu, R Dannebaum, F Rubelt, I Zlatareva, A Lorenc, Z Gracie Du, D Davies, F Kyle-Cezar, A Das et al. PNAS. 
2021     The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate. S Gee, M Chanidramani, J Seow, E Pollock, C Modestini, A Das et al. Nature Immunology. 
2020     A dynamic COVID-19 immune signature includes associations with poor prognosis. A Laing, A Lorenc, I Del Molino Del Barrio, A Das et al. Co-First author. Nature Medicine. 
2017     Adaptive from innate: Human IFN-γ+ CD4+ T cells can arise directly from CXCL8-producing recent thymic emigrants in babies and adults. Das A et al. First author: Journal of Immunology. 
2015     Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells. Pallett LJ, Gill US, Quaglia A, Sinclair LV, Lover-Cobos M, Schurich A, Singh K, Thomas N, Das A et al. Nature Medicine. 
2012     IL-10 producing regulatory B cells in the pathogenesis of chronic hepatitis B viral infection. Das A et al. First author: Journal of Immunology. 
2008     Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection. Das A et al. First author: Journal of Experimental Medicine. 
2010     CD4+ T-lymphocyte telomere length is related to fibrosis stage, clinical outcome and treatment 
response in chronic HCV infection. Hoare M, Gelson WT, Das A et al. Journal of Hepatology. 
2008     Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection. Lopes AR, Kellam P, Das A et al. Journal of Clinical Investigation.